Caprine arthritis and encephalitis8/23/2023 ![]() Lahdevirta, J., Maury, C.P.J., Teppo, A.M. ![]() Clinical Chemistry: Theory, Analysis and Correlation, (C.V. Tumor necrosis factor production in HIV-seropositive subjects. Israel-Biet, D., Cadranel, J., Beldjord, K., Andrieu, J.M., Jeffrey, A. Cholangitis associated with cholecystitis in patients with acquired immunodeficiency syndrome. Iannuzzi, C., Belghiti, J., Erlinger, S., Menu, Y. Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes. Gorrell, M.D., Brandon, M.R., Scheffer, D., Adams, R.J. Biliary disease in acquired immunodeficiency syndrome. Gallot-Lavallee-Villars, S., Romagnoli, A., de Peyer, R. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. The caprine arthritis-encephalitis syndrome. Journal of the American Veterinary Medical Association, 200, 802–805ĭawson, M., 1989. Prevalence of antibody to caprine arthritis-encephalitis virus in goats in the United States. Chronic arthritis in goats caused by a retrovirus. Journal of the American Veterinary Medical Association, 178, 713–719Ĭrawford, T.B., Adams, D.S., Cheevers, W.P. Caprine arthritis-encephalitis: clinical features and presence of antibody in selected goat populations. Journal of Infectious Diseases, 129, 134–141Ĭrawford, T.B. Infectious leukoencephalomyelitis in young goats. Laboratory Investigation, 42, 596–602Ĭork, L.C., Hadlow, W.J., Crawford, T.B., Gorham, J.R. Persistent viral infection with progressive pathological changes. The pathogenesis of viral leukoencephalitis-arthritis of goats. Current Protocols in Immunology, (Wiley, New York)Ĭork, L.C. American Journal of Veterinary Research, 44, 1670–1675Ĭoligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. Transmission and control of caprine arthritis-encephalitis virus. Depressed natural killer cell activity was observed in infected goats and may contribute towards the establishment of a persistent infection with CAEV.Īdams, D.S., Klevjer-Anderson, P. The cachexia seen in infected goats may be at least partly due to altered metabolism as a result of prolonged elevation of serum TNF-α levels. Importantly, the serum tumour necrosis factor-α (TNF-α) levels were higher in infected goats. All other serum chemistry parameters were similar between infected and control goats. The serum alkaline phosphatase and γ-glutamyl transferase concentrations were elevated in infected goats, a characteristic of hepatic and bone disorders. Infected goats showed recurrent lymphocytosis that may be due to constant presentation of antigen by infected cells of a monocyte/macrophage lineage. Various haematological and immunological parameters were evaluated in experimentally-infected goats showing typical signs of CAEV-induced disease. The immunopathogenic mechanisms responsible for these progressive clinical symptoms have not been fully elucidated. Let us know how this access is important for you.Goats infected with caprine arthritis-encephalitis virus (CAEV) show chronic arthritis and cachexia, which are progressive in nature. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. At present, the clinical consequence of CAEV-associated renal injury is not clear. Despite the TFBS conservation, the isolates demonstrated a degree of phylogenetic diversity. Within the viral promoter (U3) region, known transcription factor binding sites (TFBSs) were generally conserved, although one viral isolate had a duplication of the U3 A region encoding a second gamma-activated site (GAS). ![]() Cardiac lesions (vascular, myocardial or endocardial) were also identified in four of six animals. These goats had microscopic evidence of inflammatory renal injury (interstitial nephritis) with detectable renal immunolabeling for CAEV antigen in three of six animals and amplifiable proviral sequences consistent with CAEV in all six animals. ![]() One of the animals had CAEV antigen-associated thrombotic arteritis resulting in infarction of both the kidney and heart. Here we describe six goats with chronic, multisystemic CAEV infections in conjunction with CAEV-associated renal lesions. Clinically affected animals generally manifest with one or more of these classic CAEV-associated tissue lesions however, CAEV-associated renal inflammation in goats has not been reported in the peer-reviewed literature. Caprine arthritis encephalitis virus (CAEV) is a monocyte/macrophage-tropic lentivirus that primarily infects goats resulting in a well-recognized set of chronic inflammatory syndromes focused on the joint synovium, tissues of the central nervous system, pulmonary interstitium and mammary gland.
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